The following information provides guidelines for Milestone herbicide application around woody plants. In general, Transline® is the most selective herbicide to use for invasive plant control on sites where tree and shrub selectivity is important.
Can I use Milestone® herbicide for weed control under trees?
Aminopyralid, the active ingredient in Milestone herbicide, has limited activity on woody species, including trees, when applied to the soil under the canopy. While it would be unlikely for broadcast applications of labeled rates to actually kill a mature tree (except legume species), there could be some leaf curling/cupping or other damage typical of growth regulator herbicides. Therefore, Milestone should NOT be used over the top of desirable trees. Milestone can be used ONLY as a directed spray under the canopy, or within the dripline, of certain trees; but not under desirable legume trees/shrubs.
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Label precautions apply to forage treated with Milestone and to manure from animals that have consumed treated forage within the last three days. Consult the label for full details. Milestone is not registered for sale or use in all states. Contact your state pesticide regulatory agency to determine if a product is registered for sale or use in your state. Always read and follow label directions.
Excerpted from: Invasive Plant Management Guide for Natural Area Managers